Rat Anti-Mouse CXCR4 Monoclonal Antibody

Rat Anti-Mouse CXCR4 Monoclonal Antibody

• Description: CXCR4 (short for CXC motif chemokine receptor 4) is a receptor protein of the chemokine receptor family. CXCR4 is common in many cells of the hematopoietic system and is expressed in particular by many stem cells and tumor cells. This receptor is activated by the chemokine CXCL12 and the cytokine macrophage migration inhibitory factor (MIF). CXCR4 plays a key role in the mobilization and targeted migration of stem cells to their storage (e.g., fetal liver, bone marrow) or their sites of use in organ formation (organogenesis) and organ and wound healing. Pathophysiologically, CXCR4 is involved in tumor growth and metastatic spread as well as inflammatory processes. In addition, CXCR4 is the primary co-receptor for T cell-using (T-tropic) HI viruses.
• Synonyms: C-X-C chemokine receptor type 4, CXC-R4; CXCR-4, Fusin, Leukocyte-derived seven transmembrane domain receptor (LESTR), Pre-B-cell-derived chemokine receptor (PB-CKR), Stromal cell-derived factor 1 receptor (SDF-1 receptor)
• CAS Number: 9007-83-4
• NCBI Gene ID: 12767
• UniProt: P70658
• Accession Number: NP_034041.2
• Accession Number mRNA: NM_009911.3
• Host: Rat
• Origin Species: Mouse
• Target Antigen: Mouse Recombinant CXCR4
• Isotype: IgG2
• Clone: (#30L4)
• Validated Applications: FC, IHC
• Purification Method: Protein G chromatography
• Form: Lyophilized
• Buffer: PBS
• Reconstitution: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
• Shipping Conditions: Room Temperature
• Storage Conditions: Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.