CRTAM

CAT: 0209-101-M343Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0209-101-M343Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Human CRTAM is a 393 amino acid (aa), 80 kDa type I transmembrane glycoprotein. CRTAM is a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production. A role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed. IGSF4 is expressed broadly, including on epithelia, neurons, a subset of tonsillar B cells and a rare splenic T zone-restricted BCDA3+ dendritic cell population which interacts with CRTAM.

Synonyms

CRTAM; CD355

NCBI Gene ID

56253

UniProt

O95727

Accession Number

NP_062550.2

Accession Number mRNA

NM_019604.2

Chromosomal Location

11q24.1

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Human recombinant CRTAM extracellular domain

Clone

(#21A9)

Applications

WB, FC

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Host or Source

Mouse

Isotype

IgG2

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312106-01	CRTAM
MBS8589048-01	CRTAM Antibody
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CRTAM

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