Mouse Anti-Human Coagulation Factor XI Monoclonal Antibody

Mouse Anti-Human Coagulation Factor XI Monoclonal Antibody

• Description: Coagulation Factor XI is synthesized in the liver and circulates in the plasma as a disulfide bond-linked dimer complexed with High Molecular Weight Kininogen. Factor XI is converted into active XIa either via the contact phase of blood coagulation or through Thrombin-mediated activation on the platelet surface. The resulting XIa converts Coagulation Factor IX into IXa, which subsequently activates Coagulation Factor X (Xa). Xa then can mediate Coagulation Factor II/Thrombin activation. Patients with factor XI deficiency are prone to excessive bleeding after hemostatic challenge.
• Synonyms: F11; FXI
• CAS Number: 9007-83-4
• NCBI Gene ID: 2160
• UniProt: P03951
• Accession Number: NP_000119.1
• Accession Number mRNA: NM_000128.3
• Gene Location: 4q35
• Host: Mouse
• Origin Species: Human
• Species Reactivity: Human
• Target Antigen: Human Recombinant Coagulation factor XI
• Isotype: IgG2
• Clone: (#7C38)
• Validated Applications: WB, N
• Purification Method: Protein G chromatography
• Form: Lyophilized
• Buffer: PBS
• Reconstitution: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
• Shipping Conditions: Room Temperature
• Storage Conditions: Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.