Chemerin

• Description :

  Chemerin is a secreted chemoattractant protein that can signal through the chemokine like receptor-1 (CMKLR1) . It is expressed in various tissues, including white adipose tissue, and circulates in blood as an inactive 143 amino acid precursor protein. Biologically active Chemerin is generated by proteolytic removal of C-terminal residues by several circulating proteases. Chemerin acts as a chemoattractant for cells expressing the CMKLR1 receptor, which includes certain dendritic cells, macrophages, and adipocytes. Recombinant human Chemerin is a 15.6 kDa protein consisting of 135 amino acid residues.

• Synonyms :

  RARRES2; TIG2; HP10433

• NCBI Gene ID :

  5919

• UniProt :

  Q99969

• Accession Number :

  NP_002880.1

• Accession Number mRNA :

  NM_002889.3

• Chromosomal Location :

  7q36.1

• Reactivity :

  Human

• Cross Reactivity :

  Human

• Sequence :

  ELTEAQRRGL QVALEEFHKH PPVQWAFQET SVESAVDTPF PAGIFVRLEF KLQQTSCRKR DWKKPECKVR PNGRKRKCLA CIKLGSEDKV LGRLVHCPIE TQVLREAEEH QETQCLRVQR AGEDPHSFYF PGQFA

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to chemoattract human immature dendritic cells using a concentration range of 1.0-100 ng/ml.

• Length :

  135

• Form :

  Lyophilized

• Molecular Weight :

  15.6 kDa

• Host or Source :

  E. coli