CD80 (B7-1)

CAT: 0209-103-M144Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-103-M144Size:100 µg
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Description
B7-1 (CD80) and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be upregulated through interferon gamma. B7-1 and B7-2 are both members of the Immunoglobulin superfamily.
Synonyms
Cd80; B71; Ly53; TSA1; Cd28l; Ly-53; MIC17
NCBI Gene ID
12519
UniProt
Q00609
Accession Number
NP_033985.3
Accession Number mRNA
NM_009855.2
Chromosomal Location
16 B5; 16 28.0 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant Mouse CD80 protein
Clone
(#MAB0713)
Applications
https://www.reliatech.de/pub/media/ds/ma/103-M144.pdf
Purification Method
Protein G/A chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS (sterile)
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Armenian Hamster
Isotype
IgG

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