CD80 (B7-1)

CAT: 0209-101-M315Size: 50 µgDry Ice: NoHazardous: No
CAT#:0209-101-M315Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
B7-1 (CD80) and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be upregulated through interferon gamma. B7-1 and B7-2 are both members of the Immunoglobulin superfamily.
Synonyms
CD80; B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1
NCBI Gene ID
941
UniProt
P33681
Accession Number
NP_005182.1
Accession Number mRNA
NM_005191.3
Chromosomal Location
3q13.3-q21
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human recombinant CD80 EC domian
Clone
(#6N36)
Applications
https://www.reliatech.de/pub/media/ds/ma/101-M315.pdf
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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