CD34, soluble

• Description:

  CD34 is a highly glycosylated type I membrane protein that is selectively expressed on hematopoietic stem cells and vascular endothelium. It has been widely used as a molecular marker for the identification, isolation, and manipulation of hemopoietic stem cells and progenitors. CD34 can function as a regulator of hemopoietic cell adhesion by mediating the attachment of stem cells to bone marrow stromal cells or other bone marrow components. The full length human CD34 is a 385 amino acid protein, consisting of a 31 amino acid signal sequence, a 74 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain and a 259 amino acid extracellular domain. Recombinant human sCD34 is a 258 amino acid polypeptide containing only the extracellular domain of the full length CD34 protein.

• Synonyms:

  CD34

• NCBI Gene ID:

  947

• UniProt:

  P28906

• Accession Number:

  NP_001764.1

• Accession Number mRNA:

  NM_001773.2

• Chromosomal Location:

  1q32

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  LDNNGTATPE LPTQGTFSNV STNVSYQETT TPSTLGSTSL HPVSQHGNEA TTNITETTVK FTSTSVITSV YGNTNSSVQS QTSVISTVFT TPANVSTPET TLKPSLSPGN VSDLSTTSTS LATSPTKPYT SSSPILSDIK AEIKCSGIRE VKLTQGICLE QNKTSSCAEF KKDRGEGLAR VLCGEEQADA DAGAQVCSLL LAQSEVRPQC LLLVLANRTE ISSKLQLMKK HQSDLKKLGI LDFTEQDVAS HQSYSQKT

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  >95% by SDS-PAGE & HPLC analysis

• Bioactivity:

  Data not available.

• Length:

  258

• Form:

  Lyophilized

• Molecular Weight:

  27.3 kDa

• Host or Source:

  CHO cells