Itasetron

• Description :

  Itasetron (DA 6215) is a selective 5-HT3 receptor antagonist. Itasetron improves spatial learning and memory abilities in the aged rat. Itasetron has potent antiemetic properties. Itasetron is used for age-related memory degeneration in rodents[1][2].

• Product Name Alternative :

  DA 6215; U98079A

• UNSPSC :

  12352005

• Target :

  5-HT Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/itasetron.html

• Smiles :

  O=C1N(C2=CC=CC=C2N1)C(N[C@@H]3C[C@@H]4CC[C@@H](N4C)C3)=O

• Molecular Formula :

  C16H20N4O2

• Molecular Weight :

  300.36

• References & Citations :

  [1]N Pitsikas, et al. Itasetron (DAU 6215) prevents age-related memory deficits in the rat in a multiple choice avoidance task. Eur J Pharmacol. 1996 Sep 12;311 (2-3) :115-9. |[2]L Patoia, et al. Intravenous itasetron: establishing the effective dose range for the prophylactic control of acute emesis in cancer patients undergoing high-dose cisplatin chemotherapy. Clin Oncol (R Coll Radiol) . 1999;11 (2) :99-104.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  Lactoferrin

• CAS Number :

  [123258-84-4]