Rabbit Anti-Human CD22 Polyclonal Antibody

Rabbit Anti-Human CD22 Polyclonal Antibody

• Description: Siglec-2 (sialic acid binding Ig-like lectin 2), also known as CD22, is a 130-140 kDa type I transmembrane glycoprotein with seven Ig-like domains in the extracellular region and three ITIM motifs in its cytoplasmic region. Alternate splicing generates an additional isoform that lacks the third and fourth Ig-like domains. Siglec-2 is expressed on B cells, preferentially binds alpha 2-6 linked sialic glycans including CD45 and mediates B cell - B cell interactions. Phosphorylation of Tyr822 within one of the ITIMs is important for Siglec-2 signal transduction through its association with the kinases Lyn, PI 3-Kinase p85 alpha, and SYK.
• Synonyms: CD22; SIGLEC2; SIGLEC-2
• CAS Number: 9007-83-4
• NCBI Gene ID: 933
• UniProt: P20273
• Accession Number: NP_001762.2
• Accession Number mRNA: NM_001771.3
• Gene Location: 19q13.1
• Host: Rabbit
• Origin Species: Human
• Species Reactivity: Human
• Target Antigen: CHO cells derived Recombinant Human sCD22
• Clone: Rabbit IgG
• Validated Applications: ELISA, WB
• Purification Method: Antigen-affinity purified
• Form: Lyophilized from PBS
• Buffer: PBS
• Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
• Shipping Conditions: Room Temperature
• Storage Conditions: The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.