CART

CAT: 0209-101-M243Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-101-M243Size:100 µg
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Description
CART, also known as cocaine and amphetaminerelated transcript, is a 10 kDa secreted polypeptide produced by neuronal cell types in a variety of locations. In human, the molecule is synthesized as a 116 amino acid (aa) precursor with a 27 aa signal sequence an 89 aa mature segment. There are six Cterminal cysteines that form three intrachain disulfide bonds, and the potential exists for both sulfation and phosphorylation in the N terminal region. There are numerous monobasic and dibasic sites for enzyme cleavage, and multiple, presumably proteolyticallygenerated short forms are known to exist. These include a 5K, 48 aa peptide (CART 42- 89), and a 4.3K, 40 aa peptide (CART 49-89) . Human CART is 98% aa identical to both mouse and rat CART (189) . Although CART suppresses feeding and increases pain tolerance, there would appear to be differences between the various forms of CART on other functions. In addition, anatomical location is associated with differing lengths of CART. For example, 89 aa and 79 aa forms are found in the adrenal, while 48 aa and 44 aa forms are found in the hypothalamus.
Synonyms
CARTPT; CART
NCBI Gene ID
9607
UniProt
Q16568
Accession Number
NP_004282
Accession Number mRNA
NM_004291
Chromosomal Location
5q13.2
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human CART
Clone
(#7C11)
Applications
WB, IHC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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244237CARTPT (CART prepropeptide, CART)
MBS405973-01CART
124349CART (CART, Cocaine- and Amphetamine-regulated Transcript Protein, CART (1-39), CART (42-89) )
MBS6156880-01CART (CART, Cocaine- and Amphetamine-regulated Transcript Protein, CART(1-39), CART(42-89)) (PE)
124349-PECART (CART, Cocaine- and Amphetamine-regulated Transcript Protein, CART (1-39), CART (42-89) ) (PE)
124349-FITCCART (CART, Cocaine- and Amphetamine-regulated Transcript Protein, CART (1-39), CART (42-89) ) (FITC)
124349-APCCART (CART, Cocaine- and Amphetamine-regulated Transcript Protein, CART (1-39), CART (42-89) ) (APC)
MBS6130365-01CART (CART, Cocaine- and Amphetamine-regulated Transcript Protein, CART(1-39), CART(42-89)) (AP)
MBS6140971-01CART (CART, Cocaine- and Amphetamine-regulated Transcript Protein, CART(1-39), CART(42-89)) (Biotin)
MBS6151577-01CART (CART, Cocaine- and Amphetamine-regulated Transcript Protein, CART(1-39), CART(42-89)) (HRP)

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