4-1BB receptor, soluble Recombinant Protein

4-1BB receptor, soluble Recombinant Protein

• Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.
• Synonyms: TNFRSF9; ILA; 4-1BB; CD137; CDw137
• CAS Number: 9000-83-3
• NCBI Gene ID: 3604
• UniProt: Q07011
• Accession Number: NP_003802.1
• Accession Number mRNA: NM_001561
• Gene Location: 1p36
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human
• Sequence: MERTRSLQDP CSNCPAGTFC DNNRNQICSP CPPNSFSSAG GQRTCDICRQ CKGVFRTRKE CSSTSNAECD CTPGFHCLGA GCSMCEQDCK QGQELTKKGC KNCCFGTFND QKRGICRPWT NCSLDGKSVL VNGTKERDVV CGPSPADLSP GASSVTPPAP AREPGHS
• Detection Range: Determined by its inhibitory effect of the 4-1BBL mediated stimulation of IL-8 production by human PBMC. About 90% of inibition was seen using a concentration of 1µg for both 4-1BBL and 4-1BBR.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 97% by SDS-PAGE & HPLC analyses
• Length: 167
• Form: Lyophilized
• Molecular Weight: 17.7 kDa
• Shipping Conditions: Room Temperature