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ApoE3

CAT: 0209-100-125SSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-100-125SSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ApoE3 belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population. Recombinant human ApoE3 is a 34.0 kDa protein containing 300 amino acid residues.
Synonyms
APOE; AD2; LPG; LDLCQ5
NCBI Gene ID
348
UniProt
P02649
Accession Number
NP_000032.1
Accession Number mRNA
NM_000041.2
Chromosomal Location
19q13.2
Reactivity
Human
Cross Reactivity
Human
Sequence
MKVEQAVETE PEPELRQQTE WQSGQRWELA LGRFWDYLRW VQTLSEQVQE ELLSSQVTQE LRALMDETMK ELKAYKSELE EQLTPVAEET RARLSKELQA AQARLGADME DVCGRLVQYR GEVQAMLGQS TEELRVRLAS HLRKLRKRLL RDADDLQKRL AVYQAGAREG AERGLSAIRE RLGPLVEQGR VRAATVGSLA GQPLQERAQA WGERLRARME EMGSRTRDRL DEVKEQVAEV RAKLEEQAQQ IRLQAEAFQA RLKSWFEPLV EDMQRQWAGL VEKVQAAVGT SAAPVPSDNH
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 90% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to stimulate the proliferation of human SH-SY5Y cells.
Length
300
Form
Lyophilized
Buffer
20 mM Sodium Phosphate, pH 7.8 + 0.5 mM DTT
Molecular Weight
34.4 kDa
Host or Source
E. coli

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