ALPL

• Description:

  There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue-nonspecific) . The first three are located together on chromosome 2, whereas the tissue-nonspecific form is located on chromosome 1. The product of this gene is a membrane-bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization. However, mice that lack a functional form of this enzyme show normal skeletal development.

• Synonyms:

  Alkaline phosphatase, tissue-nonspecific isozyme, AP-TNAP; TNS-ALP, Phosphocreatine phosphatase

• NCBI Gene ID:

  249

• UniProt:

  P05186

• Accession Number:

  NP_000469.3

• Accession Number mRNA:

  NM_000478.5

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Native human ALPL

• Clone:

  (#4C67)

• Applications:

  WB

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.

• Host or Source:

  Mouse

• Isotype:

  IgG1