AITRL

• Description:

  AITRL, a member of the TNF superfamily, is expressed in endothelial cells, and signals through the AITR receptor. AITRL regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. The AITRL gene codes for a type II transmembrane protein comprised of 177 amino acids, including a 28 amino acid cytoplasmic region, a 21 amino acid transmembrane domain and a 128 amino acid extracellular domain. Recombinant human soluble AITRL is a 14.3 kDa protein, containing 126 amino acid residues corresponding to the extracellular domain of AITRL.

• Synonyms:

  TNFSF18; TL6; AITRL; GITRL; hGITRL

• NCBI Gene ID:

  8995

• UniProt:

  Q9UNG2

• Accession Number:

  NP_005083.2

• Accession Number mRNA:

  NM_005092.3

• Chromosomal Location:

  1q23

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  ETAKEPCMAKFGPLPSKWQMASSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGGTYELHVGDTIDLIFNSEHQVLKNNTYWGIILLANPQFI

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 97% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 1.0-10.0 ng/ml. Please Note: Results may vary with PBMC donors.

• Length:

  126

• Form:

  Lyophilized

• Molecular Weight:

  14.3 kDa

• Host or Source:

  E. coli