Mouse Anti-Human Aggrecan Monoclonal Antibody

Mouse Anti-Human Aggrecan Monoclonal Antibody

• Description: Aggrecan, together with type II collagen, makes up to 90% of the dry weight of healthy cartilage. It hydrates the collagen network and thus provides cartilage with its properties of compressibility and elasticity. The N-terminal region of human Aggrecan (residues 20-675) consists of two globular domains (G1 and G2), flanking an interglobular domain (IGD). The IGD contains the cleavage sites for matrix metalloproteinases and aggrecanases.
• Synonyms: ACAN; AGC1; SEDK; AGCAN; CSPG1; MSK16; CSPGCP
• CAS Number: 9007-83-4
• NCBI Gene ID: 176
• UniProt: E7ENV9
• Accession Number: NP_001126.3
• Accession Number mRNA: NM_001135.3
• Gene Location: 15q26.1
• Host: Mouse
• Origin Species: Human
• Species Reactivity: Human
• Target Antigen: Recombinant Human Aggrecan
• Isotype: IgG2
• Clone: (#23A8)
• Validated Applications: WB, IHC (P)
• Purification Method: Protein G chromatography
• Form: Lyophilized
• Buffer: PBS
• Reconstitution: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
• Shipping Conditions: Room Temperature
• Storage Conditions: Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.