Aggrecan

• Description:

  Aggrecan, together with type II collagen, makes up to 90% of the dry weight of healthy cartilage. It hydrates the collagen network and thus provides cartilage with its properties of compressibility and elasticity. The N-terminal region of human Aggrecan (residues 20-675) consists of two globular domains (G1 and G2), flanking an interglobular domain (IGD) . The IGD contains the cleavage sites for matrix metalloproteinases and aggrecanases.

• Synonyms:

  ACAN; AGC1; SEDK; AGCAN; CSPG1; MSK16; CSPGCP

• NCBI Gene ID:

  176

• UniProt:

  E7ENV9

• Accession Number:

  NP_001126.3

• Accession Number mRNA:

  NM_001135.3

• Chromosomal Location:

  15q26.1

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Recombinant human Aggrecan

• Clone:

  (#23A8)

• Applications:

  WB, IHC (P)

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Mouse

• Isotype:

  IgG2