Aggrecan

• Description :

  Aggrecan, together with type II collagen, makes up to 90% of the dry weight of healthy cartilage. It hydrates the collagen network and thus provides cartilage with its properties of compressibility and elasticity. The N-terminal region of human Aggrecan (residues 20-675) consists of two globular domains (G1 and G2), flanking an interglobular domain (IGD) . The IGD contains the cleavage sites for matrix metalloproteinases and aggrecanases.

• Synonyms :

  ACAN; AGC1; SEDK; AGCAN; CSPG1; MSK16; CSPGCP

• NCBI Gene ID :

  176

• UniProt :

  E7ENV9

• Accession Number :

  NP_001126.3

• Accession Number mRNA :

  NM_001135.3

• Chromosomal Location :

  15q26.1

• Reactivity :

  Anti-Human

• Cross Reactivity :

  Human

• Target Antigen :

  Recombinant human Aggrecan

• Clone :

  (#23A8)

• Applications :

  WB, IHC (P)

• Purification Method :

  Protein G chromatography

• Assay Protocol :

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form :

  Lyophilized

• Buffer :

  PBS

• Reconstitution :

  PBS

• Storage Conditions :

  Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source :

  Mouse

• Isotype :

  IgG2