Adiponectin

• Description:

  Adiponectin is an adipose-derived secreted protein containing 226 amino acid residues. It is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma protein. The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. Disruption of adiponectin in mice causes insulin resistance and neointimal formation. Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-α and class A scavenger receptor in macrophages) .

• Synonyms:

  Acrp-30, GBP-28, APM-1, Gelatin-binding protein, AdipoQ

• NCBI Gene ID:

  9370

• UniProt:

  Q15848

• Accession Number:

  NP_001171271

• Accession Number mRNA:

  NM_001177800

• Chromosomal Location:

  3q27

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Hi-5 Insect cells derived Recombinant Human Adiponectin (#100-121)

• Clone:

  Rabbit IgG

• Applications:

  WB, ELISA

• Purification Method:

  Antigen-affinity purified

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

• Bioactivity:

  WB: 0.1-0.2 μg/ml

• Form:

  Lyophilized

• Reconstitution:

  Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

• Storage Conditions:

  The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.

• Host or Source:

  Rabbit

• Isotype:

  Rabbit IgG