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PQCA

CAT: 0804-HY-118342-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118342-01Size:1 mg
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Description
PQCA is a highly selective and potent muscarinic M1 receptor positive allosteric modulator. PQCA has an EC50 value of 49 nM and 135 nM on rhesus and human M1 receptor, respectively. PQCA is inactive for other muscarinic receptors. PQCA has potential to reduce the cognitive deficits associated with Alzheimer's disease[1][2].
CAS Number
1144504-35-7
Product Name Alternative
CA-074Me
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pqca.html
Purity
99.96
Solubility
1 M NaOH : 2 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 10 mg/mL (ultrasonic; warming; adjust pH to 8 with 1 M NaOH; heat to 60°C) |Methanol : 50 mg/mL (ultrasonic; adjust pH to 11 with NaOH)
Smiles
O=C(O)C1=CC(CN2CCC(C#N)(CC2)C3=NC=CC=C3)=C4C=CC=CN4C1=O
Molecular Formula
C22H20N4O3
Molecular Weight
388.42
References & Citations
[1]Lange HS, et al. The M1 Muscarinic Positive Allosteric Modulator PQCA Improves Performance on Translatable Tests of Memory and Attention in Rhesus Monkeys. J Pharmacol Exp Ther. 2015 Dec;355 (3) :442-50.|[2]Uslaner JM, et al. The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque. Psychopharmacology (Berl) . 2013 Jan;225 (1) :21-30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR1

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CatalogName
GTR19205081-01PQCA

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