NIH-12848

• Description :

  NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM.

• CAS Number :

  [959551-10-1]

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  PI5P4K

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/NIH-12848.html

• Purity :

  99.96

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  FC(C1=CC=CC=C1C2=NC(NCC3=CC=CS3)=C4C=CC=CC4=N2)(F)F

• Molecular Formula :

  C20H14F3N3S

• Molecular Weight :

  385.41

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Clarke JH, et al. The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site. Biochem J. 2015 Mar 1;466 (2) :359-67.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported