Zinc Phytate

• Description:

  Zinc Phytate (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound. Zinc Phytate can be derived from the seeds of legumes. Zinc Phytate is a [PO4]3- storage depot and precursor for other inositol phosphates and pyrophosphates. Zinc Phytate attenuates Aβ oligomers and upregulates autophagy protein. Zinc Phytate can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research[1][2][3][4][5][6][7][8][9][10].

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Amyloid-β; Autophagy; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Metabolic Disease; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/zinc-phytate.html

• Purity:

  98.20

• Solubility:

  H2O : 50 mg/mL (48.07 mM; Need ultrasonic) |10%TFA : 50 mg/mL (48.07 mM; ultrasonic and adjust pH to 2 with 10%TFA)

• Smiles:

  O=P([O-])([O-])O[C@H]([C@H]([C@H](OP([O-])([O-])=O)[C@H]1OP([O-])([O-])=O)OP([O-])([O-])=O)[C@H]([C@H]1OP([O-])([O-])=O)OP([O-])([O-])=O.[Zn+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2]

• Molecular Formula:

  C6H6O24P6Zn6

• Molecular Weight:

  1040.22

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Shears SB, et al.Assessing the omnipotence of inositol hexakisphosphate.Cell Signal. 2001 Mar;13 (3) :151-8.|[2]Kim NH, et al. Phytic Acid and Sodium Chloride Show Marked Synergistic Bactericidal Effects against Nonadapted and Acid-Adapted Escherichia coli O157:H7 Strains. Appl Environ Microbiol. 2015 Dec 4;82 (4) :1040-1049. |[3]Fu Q, et al. The effect of phytic acid on tight junctions in the human intestinal Caco-2 cell line and its mechanism. Eur J Pharm Sci. 2015 Dec 1;80:1-8.|[4]Woyengo TA, et al. Effect of dietary phytic acid on performance and nutrient uptake in the small intestine of piglets. J Anim Sci. 2012 Feb;90 (2) :543-9.|[5]Anekonda TS, et al. Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models. J Alzheimers Dis. 2011;23 (1) :21-35. |[6]Eberhard M, et al. Effect of phytic acid on suicidal erythrocyte death. J Agric Food Chem. 2010 Feb 10;58 (3) :2028-33.|[7]Obata T, et al. Phytic acid suppresses ischemia-induced hydroxyl radical generation in rat myocardium. Eur J Pharmacol. 2016 Mar 5;774:20-4.|[8]Xu Z, et al. Protective effects of phytic acid on CCl4‐induced liver fibrosis in mice. Journal of Food Biochemistry, 2023, 2023 (1) : 6634450.|[9]Omoruyi FO, et al. The potential benefits and adverse effects of phytic Acid supplement in streptozotocin-induced diabetic rats. Adv Pharmacol Sci. 2013;2013:172494. |[10]Verghese M, et al. Anticarcinogenic effect of phytic acid (IP6) : apoptosis as a possible mechanism of action. LWT-Food Science and Technology, 2006, 39 (10) : 1093-1098.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  [63903-51-5]