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MM0299

CAT: 0804-HY-160972-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-160972-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MM0299 is an inhibitor for lanosterol synthase (LSS) with an IC50 of 2.2 μM. MM0299 inhibits cell proliferation of Mut6 with an IC50 of 0.0182 μM, through generation of 24 (S),25-epoxycholesterol (EPC) and the depletion of cellular cholesterol[1].
CAS Number
474255-10-2
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mm0299.html
Purity
98.51
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N1C(C=C2)=CC=C2OCC(C(C=C3)=CC=C3OC)=O)C4C(C1=O)[C@@H]5[C@@H]6C(C6)[C@H]4C=C5
Molecular Formula
C26H23NO5
Molecular Weight
429.46
References & Citations
[1]Nguyen TP, et al., Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24 (S),25-epoxycholesterol production. Cell Chem Biol. 2023 Feb 16;30 (2) :214-229.e18.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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