Atogepant

• Description :

  Atogepant (MK-8031) is an orally active and selective calcitonin gene-related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine[1][2].

• Product Name Alternative :

  MK-8031; AGN-241689

• UNSPSC :

  12352005

• Target :

  CGRP Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/atogepant.html

• Purity :

  99.93

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1[C@]2(CC3=CC(C(N[C@H]4C[C@](C5=C(C(F)=CC=C5F)F)([H])[C@H](N(C4=O)CC(F)(F)F)C)=O)=CN=C3C2)C6=CC=CN=C6N1

• Molecular Formula :

  C29H23F6N5O3

• Molecular Weight :

  603.52

• References & Citations :

  [1]Ailani J, et al. Atogepant for the Preventive Treatment of Migraine. N Engl J Med. 2021 Aug 19;385 (8) :695-706.|[2]Moore E, et al. Pharmacologic characterization of atogepant: A potent and selective calcitonin gene–related peptide receptor antagonist. Cephalalgia. 2024;44 (1)

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [1374248-81-3]