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Mericitabine

CAT: 0804-HY-10240-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10240-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.
CAS Number
940908-79-2
Product Name Alternative
RG 7128; R-7128; PSI 6130 diisobutyrate
UNSPSC
12352005
Target
HCV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/R-7128.html
Purity
99.07
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N=C(C=CN1[C@@H]([C@@](C)([C@@H]2OC(C(C)C)=O)F)O[C@@H]2COC(C(C)C)=O)N
Molecular Formula
C18H26FN3O6
Molecular Weight
399.41
References & Citations
[1]Le Pogam S, et al. Characterization of HCV quasispecies dynamics upon short term dual-therapy with the HCV NS5B nucleoside polymerase inhibitor mericitabine and the NS3/4 protease inhibitor danoprevir. Antimicrob Agents Chemother. 2012 Nov;56 (11) :5494-5|[2]Soriano V, et al. Directly acting antivirals against hepatitis C virus. J Antimicrob Chemother. 2011 Aug;66 (8) :1673-86|[3]Guedj J, et al. Hepatitis C viral kinetics with the nucleoside polymerase inhibitor mericitabine (RG7128) . Hepatology. 2012 Apr;55 (4) :1030-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
MBS386838-01Mericitabine
A11539-100Mericitabine 100mg
A11539-50Mericitabine 50mg
A11539-25Mericitabine 25mg
A11539-5Mericitabine 5mg
A11539-10Mericitabine 10mg
A11539-200Mericitabine 200mg
A11539-1Mericitabine 1mg
A11539-10mM-DMericitabine 10mM * 1mL in DMSO

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