Products for Research Use Only
RegisterLogin

Talazoparib Tosylate

CAT: 0572-TRC-T137340-100MGSize: 100 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0572-TRC-T137340-100MGSize:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1373431-65-2
Synonyms
BMN 673ts;
Hazard Statement
Toxic if swallowed; UN number: UN2811; Packing Group: III
Purity
>95% (HPLC)
Smiles
Cc1ccc(cc1)S(=O)(=O)O.Cn2ncnc2[C@@H]3[C@H](Nc4cc(F)cc5C(=O)NN=C3c45)c6ccc(F)cc6
Molecular Formula
C19H14F2N6O . C7H8O3S
Shipping Conditions
Room Temperature
Storage Conditions
-20°C

Chemical Information

Talazoparib Tosylate

Talazoparib Tosylate is the tosylate salt form of talazoparib, an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Upon administration, talazoparib selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks.

CAS Number1373431-65-2
PubChem CID135565654
IUPAC Name(11S,12R)-7-fluoro-11-(4-fluorophenyl)-12-(2-methyl-1,2,4-triazol-3-yl)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1,5(13),6,8-tetraen-4-one;4-methylbenzenesulfonic acid
Molecular FormulaC26H22F2N6O4S
Molecular Weight552.6
Topological Polar Surface Area147
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count3
Heavy Atom Count39
Formal Charge0
Complexity861
SMILES
CC1=CC=C(C=C1)S(=O)(=O)O.CN1C(=NC=N1)[C@@H]2[C@H](NC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(C=C5)F
InChI
InChI=1S/C19H14F2N6O.C7H8O3S/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28;1-6-2-4-7(5-3-6)11(8,9)10/h2-8,15-16,24H,1H3,(H,26,28);2-5H,1H3,(H,8,9,10)/t15-,16-;/m1./s1
InChIKey
QUQKKHBYEFLEHK-QNBGGDODSA-N
Chemical Structure
2D Structure
2D structure of Talazoparib Tosylate
CAS: 1373431-65-2
CID: 135565654
Formula: C26H22F2N6O4S
MW: 552.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight552.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count3
Exact Mass552.13913070
Monoisotopic Mass552.13913070
Topological Polar Surface Area147 Ų
Heavy Atom Count39
Formal Charge0
Complexity861
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
TRC-A108505-250MGAbiraterone Tosylate
TRC-E927065-1GEthyl Tosylate
TRC-S676845-10GSorafenib Tosylate
TRC-B677370-10MGBretylium Tosylate
TRC-P338280-1GPhenyl Tosylate
TRC-C586950-1GClofilium Tosylate
TRC-S676845-1GSorafenib Tosylate
TRC-P205850-25MGParoxol Tosylate
TRC-P766010-10GPropargyl Tosylate
TRC-N481405-5MGNiraparib Tosylate

Alternative Products

CatalogName
MBS3844687-01Talazoparib tosylate
A20238-10Talazoparib tosylate 10mg
A20238-200Talazoparib tosylate 200mg
A20238-50Talazoparib tosylate 50mg
A20238-5Talazoparib tosylate 5mg
A20238-100Talazoparib tosylate 100mg
A20238-25Talazoparib tosylate 25mg
A20238-2Talazoparib tosylate 2mg
A20238-10mM-DTalazoparib tosylate 10mM * 1mL in DMSO
204710Talazoparib

Popular Products