SecinH3

• Description :

  SecinH3 is an antagonist of cytohesins with IC50s of 5.4 μM, 2.4 μM, 5.4 μM, 5.6 μM, 5.6 μM and 65 μM for hCyh1, hCyh2, mCyh3, hCyh3, drosophila steppke and yGea2-S7, respectively.

• CAS Number :

  [853625-60-2]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Endocrinology; Metabolic Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/SecinH3.html

• Purity :

  99.70

• Solubility :

  DMSO : 130 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1=CC=C(N2N=C(OC)N=C2C3=CC=C(OCO4)C4=C3)C=C1)CSC5=CC=CC=C5

• Molecular Formula :

  C24H20N4O4S

• Molecular Weight :

  460.51

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Hafner M, et al. Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance. Nature. 2006 Dec 14;444 (7121) :941-4.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported