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Eg5-IN-3

CAT: 0804-HY-162518Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162518Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Eg5-IN-3 (5) is an Eg5 inhibitor that targets the novel allosteric pocket (α4/α6/L11). Eg5-IN-3 (5) causes tubulin assembly distortion with irregular morphology, resulting in a typical mitotic arrest similar to Monastrol.
UNSPSC
12352005
Target
Kinesin; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/eg5-in-3.html
Smiles
CN1C(N=C(NCCCN2C=NC=C2)N3CC4=CC=C(C=CC=C5)C5=C4)=C3C(NC1=O)=O
Molecular Formula
C23H23N7O2
Molecular Weight
429.47
References & Citations
[1]Samia A Elseginy, et al. Identifying and characterising promising small molecule inhibitors of kinesin spindle protein using ligand-based virtual screening, molecular docking, molecular dynamics and MM‑GBSA calculations. J Comput Aided Mol Des. 2024 Apr 1;38 (1) :16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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