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LY450108

CAT: 0804-HY-10935-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10935-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY450108 is a potent AMPA receptor potentiator. LY450108 has the potential for depression and Parkinson's disease research[1][2][3][4].
CAS Number
376594-67-1
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/LY450108.html
Purity
99.51
Solubility
DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL
Smiles
FC1=CC(F)=CC(C(NC2=CC=C([C@@H](C)CNS(C(C)C)(=O)=O)C=C2)=O)=C1
Molecular Formula
C19H22F2N2O3S
Molecular Weight
396.45
References & Citations
[1]Simon E Ward1, Benjamin D Bax, Mark Harries. Challenges for and current status of research into positive modulators of AMPA receptors. British Journal of Pharmacology. 2010,160 (2) :181-190.|[2]O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8 (5) :603-20.|[3]Jhee SS, Chappell AS, Zarotsky V, et al. Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects. J Clin Pharmacol. 2006 Apr;46 (4) :424-32.|[4]Douglas A. Schober, Martin B. Gill, Hong Yu, et al. Transmembrane AMPA Receptor Regulatory Proteins and Cornichon-2 Allosterically Regulate AMPA Receptor Antagonists and Potentiators. The Journal of Biological Chemistry, 286, 13134-13142.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor

Alternative Products

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TQ0289-01LY450108
A12425-50LY450108 50mg
A12425-100LY450108 100mg
A12425-25LY450108 25mg
A12425-200LY450108 200mg
A12425-5LY450108 5mg
A12425-10LY450108 10mg
A12425-2LY450108 2mg
A12425-10mM-DLY450108 10mM * 1mL in DMSO

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