B-AP15

• Description:

  B-AP15 is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14.

• Product Name Alternative:

  NSC 687852

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; Deubiquitinase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/b-AP15.html

• Purity:

  98.93

• Solubility:

  DMSO : 20 mg/mL (ultrasonic)

• Smiles:

  O=C1/C(CN(C(C=C)=O)C/C1=C\C2=CC=C([N+]([O-])=O)C=C2)=C/C3=CC=C([N+]([O-])=O)C=C3

• Molecular Formula:

  C22H17N3O6

• Molecular Weight:

  419.39

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]D'Arcy P, et al. Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat Med. 2011 Nov 6;17 (12) :1636-40.|[2]Wang X, et al. The 19S Deubiquitinase Inhibitor b-AP15 is Enriched in Cells and Elicits Rapid Commitment to Cell Death. Mol Pharmacol. 2014 Jun;85 (6) :932-45.|[3]Tian Z, et al. A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood. 2014 Jan 30;123 (5) :706-16.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1009817-63-3]