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Hydroxyzine Dihydrochloride

CAT: 0572-TRC-H996500-1GSize: 1 gDry Ice: NoHazardous: No
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CAT#:0572-TRC-H996500-1GSize:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2192-20-3
Synonyms
Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, hydrochloride (1:2); Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride (9CI); 1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]diethylenediamine dihydrochloride; Alamon; Atarax; Atarax P Parenteral soln.; Atarax dihydrochloride; Aterax; Atranine A; Durrax; Hydroxizine chloride; Hydroxyzine dihydrochloride; Hydroxyzine hydrochloride; Hydroxyzyne hydrochloride; Neurolax; Orgatrax; QYS; Quiess; Vistaril Parenteral; Vistaril Steraject; Ethanol, 2-[2-[4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl]ethoxy]-, dihydrochloride (8CI); 2-[2-[4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol dihydrochloride
Hazard Statement
Harmful if swallowed
Purity
>95% (HPLC)
Smiles
Cl.Cl.OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3
Molecular Formula
C21 H27 Cl N2 O2 . 2 Cl H
Molecular Weight
447.83
InChI
InChI=1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H
Additionnal Information
IUPAC name: 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol;dihydrochloride
Shipping Conditions
Room Temperature
Storage Conditions
+4°C

Chemical Information

Hydroxyzine Hydrochloride

Hydroxyzine Hydrochloride is the hydrochloride salt form of hydroxyzine, a piperazine histamine H1-receptor antagonist with anti-allergic, antispasmodic, sedative, anti-emetic and anti-anxiety properties. Hydroxyzine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. In addition, hydroxyzine hydrochloride crosses the blood-brain barrier and acts on the histamine H1-receptors in the central nervous system. (NCI05)

CAS Number2192-20-3
PubChem CID91513
IUPAC Name2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol;dihydrochloride
Molecular FormulaC21H29Cl3N2O2
Molecular Weight447.8
Topological Polar Surface Area35.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Heavy Atom Count28
Formal Charge0
Complexity376
SMILES
C1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl
InChI
InChI=1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H
InChIKey
ANOMHKZSQFYSBR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Hydroxyzine Hydrochloride
CAS: 2192-20-3
CID: 91513
Formula: C21H29Cl3N2O2
MW: 447.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight447.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Exact Mass446.129461
Monoisotopic Mass446.129461
Topological Polar Surface Area35.9 Ų
Heavy Atom Count28
Formal Charge0
Complexity376
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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FH24516-01Hydroxyzine dihydrochloride
HY-B0548A-01Hydroxyzine (dihydrochloride)
HY-B0548AS-01Hydroxyzine-d4 (dihydrochloride)
TMIH-0273-01Hydroxyzine dihydrochloride-d10
CS-SN-00041Hydroxyzine-d8 Dihydrochloride
CS-O-06666Hydroxyzine-d4 Dihydrochloride
HY-B0548AS2Hydroxyzine-d8 (dihydrochloride)
HY-B0548AS1-01Hydroxyzine-d4' (dihydrochloride)
RM-H250427-01Hydroxyzine D4 Dihydrochloride
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