Iota-conotoxin RXIA

Iota-conotoxin RXIA

• CAS Number: 1042682-52-9
• UNSPSC Description: lota-conotoxin RXIA is an agonist of voltage-gated sodium channels (Nav1.2, 1.6, 1.7). Iota-conotoxin RXIA can induce repetitive action potential and seizure in motor axons of frogs after intracranial injection in mice [1].
• Target Antigen: Sodium Channel
• Type: Peptides
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Solubility: 10 mM in DMSO
• Smiles: O=C(CN)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CSSCC(NC4=O)C(N[C@H](C(N5[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N6[C@H](C(NC7)=O)CCC6)=O)CC(C)C)=O)[C@H](CC)C)=O)CC8=CNC9=CC=CC=C89)=O)CC(N)=O)=O)[C@@H](C)O)=O)CO)=O)C[C@H](C5)O)=O)C)=O)=O)CC(O)=O)=O)C)=O)CC%10=CNC=N%10)=O)CC%11=CC=C(O)C=C%11)=O)CCC(O)=O)=O)CSSC[C@H](NC%12=O)C(N[C@H](C(N[C@H](C(NCC(N[C@H]4[C@H](CC)C)=O)=O)CO)=O)CC(C)C)=O)=O)C[C@H](C2)O)=O)CCCCN)=O)CCC(O)=O)=O)CC(O)=O)=O)C)=O)CCCCN)=O)CSSC[C@H](NC3=O)C(NC(C(N[C@H]%12CSSC[C@H](NC7=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)[C@H](CC)C)=O)CCCCN)=O)CC%13=CC=CC=C%13)=O)CC%14=CC=CC=C%14)=O)CO)=O)CO)=O)[C@@H](C)O)=O)CO)=O)=O)CC(N)=O)=O)=O)CC%15=CC=CC=C%15)=O)CO)=O)C[C@H](C1)O
• Molecular Weight: 4975.57
• References & Citations: [1]Fiedler B, et al. Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7. Biochem Pharmacol. 2008 Jun 15;75(12):2334-44.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported