Prothionamide (Standard)

CAT: 0804-HY-B0306R-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0306R-01Size:10 mg
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Description
Prothionamide (Standard) is the analytical standard of Prothionamide (HY-B0306) . This product is intended for research and analytical applications. Prothionamide is an orally active thioamide antibacterial agent. Prothionamide is a substrate of OCT1 with a Km value of 805.8 μM. Prothionamide reacts with NAD to form a covalent adduct, with the adduct being a tight-binding inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae InhA. Prothionamide can effectively inhibit the growth of Mycobacterium tuberculosis (MIC = ~0.5 µg/mL) and Mycobacterium leprae. Prothionamide is used in the research of tuberculosis and leprosy[1][2][3][4][5].
CAS Number
[14222-60-7]
Product Name Alternative
Protionamide (Standard)
UNSPSC
12352005
Target
Bacterial; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Others
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/prothionamide-standard.html
Smiles
S=C(C1=CC(CCC)=NC=C1)N
Molecular Formula
C9H12N2S
Molecular Weight
180.27
References & Citations
[1]Wang F, et al. Mechanism of thioamide drug action against tuberculosis and leprosy.J Exp Med. 2007 Jan 22;204 (1) :73-8.|[2]Fajardo TT, et al. A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy. Am J Trop Med Hyg. 2006 Mar;74 (3) :457-61.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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