RITA

• Description:

  RITA is an inhibitor of p53-HDM-2 interaction, binds to p53dN, with a Kd of 1.5 nM, and also induces DNA-DNA cross-links.

• Product Name Alternative:

  NSC 652287

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Autophagy; DNA Alkylator/Crosslinker; MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/rita.html

• Purity:

  99.79

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  OCC1=CC=C(C2=CC=C(C3=CC=C(CO)S3)O2)S1

• Molecular Formula:

  C14H12O3S2

• Molecular Weight:

  292.37

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Issaeva N, et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med. 2004 Dec;10 (12) :1321-8. Epub 2004 Nov 21.|[2]Nieves-Neira W, et al. DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells. Mol Pharmacol. 1999 Sep;56 (3) :478-84.|[3]Zhao CY, et al. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res. 2010 Apr 15;70 (8) :3372-81.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [213261-59-7]