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Alpinetin

CAT: 0804-HY-N0625A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0625A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alpinetin is a flavonoid isolated from cardamom and possesses antitumor, antiinflammation, hepatoprotective, cardiovascular protective, lung protective, antibacterial, antiviral, neuroprotective properties. Alpinetin inhibits lipopolysaccharide (LPS) -induced inflammation, activates PPAR-γ, activates Nrf2, and inhibits TLR4 expression to protect LPS-induced renal injury[1][2][3][4].
CAS Number
36052-37-6
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Keap1-Nrf2; PPAR; Toll-like Receptor (TLR)
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/alpinetin.html
Purity
99.51
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C[C@@H](C2=CC=CC=C2)OC3=CC(O)=CC(OC)=C13
Molecular Formula
C16H14O4
Molecular Weight
270.28
Precautions
H315, H319, H335
References & Citations
[1]Hu K, et al. Alpinetin inhibits LPS-induced inflammatory mediator response by activating PPAR-γ in THP-1-derived macrophages. Eur J Pharmacol. 2013 Dec 5;721 (1-3) :96-102.|[2]Zhao G, et al. Alpinetin: A Review of Its Pharmacology and Pharmacokinetics. Front Pharmacol. 2022 Feb 4;13:814370.|[3]Gul S, et al. Alpinetin: a Dietary Flavonoid with Diverse Anticancer Effects. Appl Biochem Biotechnol. 2022 Sep;194 (9) :4220-4243.|[4]Liang Y, et al. Alpinetin ameliorates inflammatory response in LPS-induced endometritis in mice. Int Immunopharmacol. 2018 Sep;62:309-312.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PPARγ

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