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IPG7236

CAT: 0804-HY-153670-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153670-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IPG7236 is a selective and orally active CC chemokine receptor 8 (CCR8) antagonist with an IC50 of 24 nM in a Tango assay. IPG7236 effectively inhibits the downstream signaling of CCR8 induced by CCL1 (IC50 = 8.44 nM), CCL1-induced downstream signaling in the CCR8-overexpressing cells (IC50 = 24.3 nM), and CCL1-induced CCR8+ Treg cells’ migration (IC50 = 33.8 nM) .IPG7236 demonstrates an anti-cancer effect via up-regulating Treg and down-regulating cytotoxic T (CD8+ T) cells. IPG7236 can used for the study of breast cancer[1].
CAS Number
2756350-91-9
UNSPSC
12352005
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ipg7236.html
Purity
98.54
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C=CC=C1)C)NC2=C(C=C(C=C2)S(N[C@@H](C3CCN(CC3)C)C)(=O)=O)C
Molecular Formula
C23H31N3O3S
Molecular Weight
429.58
References & Citations
[1]Wu Y, et al. Discovery of a Potent and Selective CCR8 Small Molecular Antagonist IPG7236 for the Treatment of Cancer. J Med Chem. 2023 Apr 13;66 (7) :4548-4564.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CCR8

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CatalogName
BA5257-5IPG7236

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