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DS2

CAT: 0804-HY-103520-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103520-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DS2 is a selective positive allosteric modulator of δ-GABAA receptor. DS2 selectively potentiates GABA responses mediated by α4β3δ receptor. DS2 does not enhance activity at α4β3γ2 and α1β3γ2 receptors. DS2 relieves pain and has the potential for sleep disorders research[1].
CAS Number
374084-31-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ds2.html
Purity
99.94
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=C(C2=CC=CS2)N=C3C=CC=CN31)C4=CC=C(Cl)C=C4
Molecular Formula
C18H12ClN3OS
Molecular Weight
353.83
Precautions
H302, H315, H319, H335
References & Citations
[1]K A Wafford, et al. Novel compounds selectively enhance delta subunit containing GABA A receptors and increase tonic currents in thalamus. Neuropharmacology. 2009 Jan;56 (1) :182-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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