ZINC12409120

CAT: 0804-HY-150687-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-150687-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

ZINC12409120 is a high selective ERK inhibitor. ZINC12409120 acts on disrupting FGF23:α-Klotho interaction to inhibit ERK activity with an IC50 of 5.0 μM[1].

CAS Number

1010888-06-8

UNSPSC

12352005

Target

ERK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/zinc12409120.html

Purity

99.95

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1CC2=C(C=CC=C2)CC1)C3=NC(C4=CC=CC5=C4C=CN5)=NO3

Molecular Formula

C20H16N4O2

Molecular Weight

344.37

References & Citations

[1]Liu SH, et al. Identification of Small-Molecule Inhibitors of Fibroblast Growth Factor 23 Signaling via In Silico Hot Spot Prediction and Molecular Docking to α-Klotho. J Chem Inf Model. 2022 Jul 22.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ERK

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