Rhein

• Description:

  Rhein is an anthraquinone compound with anti-inflammatory, antioxidant, and anti-cancer effects[1].

• Product Name Alternative:

  Rheic Acid; Rhubarb yellow; Monorhein

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Apoptosis; Autophagy; Bacterial; Reactive Oxygen Species (ROS)

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer; Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Rhein.html

• Purity:

  99.73

• Solubility:

  DMSO : 7.14 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(C(C=C1C2=O)=CC(O)=C1C(C3=C2C=CC=C3O)=O)O

• Molecular Formula:

  C15H8O6

• Molecular Weight:

  284.22

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Hou ML, et al. The Drug-Drug Effects of Rhein on the Pharmacokinetics and Pharmacodynamics of Clozapine in Rat Brain Extracellular Fluid by In Vivo Microdialysis. J Pharmacol Exp Ther. 2015 Oct;355 (1) :125-34.|[2]Heo SK, et al. Rhein augments ATRA-induced differentiation of acute promyelocytic leukemia cells. Phytomedicine. 2018 Oct 1;49:66-74.|[3]Zhao YL, et al. Rhein protects against acetaminophen-induced hepatic and renal toxicity. Food Chem Toxicol. 2011 Aug;49 (8) :1705-10. |[4]Fernand VE, et al. Rhein inhibits angiogenesis and the viability of hormone-dependent and -independent cancer cells under normoxic or hypoxic conditions in vitro. Chem Biol Interact. 2011 Jul 15;192 (3) :220-32.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [478-43-3]