SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3

SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3

• CAS Number: 1373170-36-5
• UNSPSC Description: SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 is a Drug-Linker Conjugate for ADC. SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 consists of the anti-cancer agent SN38 (HY-13704) and a linker Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 (HY-131157). SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 can be used for synthesis of ADCs[1]. SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
• Target Antigen: Drug-Linker Conjugates for ADC
• Type: Reference compound
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/sn38-pab-lys-mmt-oxydiacetamide-peg8-n3.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C1[C@](OC(OCC2=CC=C(NC([C@@H](NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)CCCCNC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=C(OC)C=C5)=O)C=C2)=O)(CC)C6=C(CO1)C(N7CC8=C(CC)C9=CC(O)=CC=C9N=C8C7=C6)=O
• Molecular Weight: 1478.64
• References & Citations: [1]Govindan Serengulam V, et al. Antibody-SN-38 immunoconjugates with a CL2A linker. Patent. US20140227180.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported