Aleniglipron

CAT: 0804-HY-160734-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-160734-01Size:5 mg

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Description

Aleniglipron (compound 121a) (GSBR-1290) is a GLP-1 agonist with an EC50 value of less than 0.1 nM in the HDB cell line in a cAMP stimulation assay[1].

CAS Number

2685823-26-9

Product Name Alternative

GSBR-1290

UNSPSC

12352005

Target

GLP Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/aleniglipron.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@H]1[C@](N2C3=CC=C(C4CCOCC4)C=C3C=C2C(N5[C@H](C6=C(N7C(N(C8=CC(NC)=C(C=C8)P(CC)(CC)=O)C=C7)=O)N(C9=CC(C)=C(C(C)=C9)F)N=C6CC5)C)=O)(C%10=NOC(N%10)=O)C1

Molecular Formula

C49H55FN9O6P

Molecular Weight

915.99

References & Citations

[1]Qinghua Meng, et al. Heterocyclic glp-1 agonists. WO2023016546. 2022-08-12.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Chemical Information

Aleniglipron

GSBR-1290 is a small molecule agonist of the GLP-1 receptor.

CAS Number	2685823-26-9
PubChem CID	164809721
IUPAC Name	3-[(1S,2S)-1-[2-[(4S)-3-[3-[4-diethylphosphoryl-3-(methylamino)phenyl]-2-oxoimidazol-1-yl]-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]-5-(oxan-4-yl)indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one
Molecular Formula	C49H55FN9O6P
Molecular Weight	916.0
XLogP	6.7
Topological Polar Surface Area	156
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	11
Heavy Atom Count	66
Formal Charge	0
Complexity	1950

SMILES

CCP(=O)(CC)C1=C(C=C(C=C1)N2C=CN(C2=O)C3=C4[C@@H](N(CCC4=NN3C5=CC(=C(C(=C5)C)F)C)C(=O)C6=CC7=C(N6[C@]8(C[C@@H]8C)C9=NOC(=O)N9)C=CC(=C7)C1CCOCC1)C)NC

InChI

InChI=1S/C49H55FN9O6P/c1-8-66(63,9-2)41-13-11-35(26-38(41)51-7)56-18-19-57(48(56)62)44-42-31(6)55(17-14-37(42)53-59(44)36-22-28(3)43(50)29(4)23-36)45(60)40-25-34-24-33(32-15-20-64-21-16-32)10-12-39(34)58(40)49(27-30(49)5)46-52-47(61)65-54-46/h10-13,18-19,22-26,30-32,51H,8-9,14-17,20-21,27H2,1-7H3,(H,52,54,61)/t30-,31-,49-/m0/s1

InChIKey

CPOJUYUGONJVPZ-WIXASUBBSA-N

Chemical Structure

2D Structure

CAS: 2685823-26-9

CID: 164809721

Formula: C49H55FN9O6P

MW: 916.0

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	916.0
XLogP3	6.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	11
Exact Mass	915.39969567
Monoisotopic Mass	915.39969567
Topological Polar Surface Area	156 Å²
Heavy Atom Count	66
Formal Charge	0
Complexity	1950
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
T200674-01	Aleniglipron
C18514-5mg	Aleniglipron (GSBR-1290)

Aleniglipron

Chemical Information

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