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MeOIstPyrd

CAT: 0804-HY-155974-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-155974-01Size:5 mg
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Description
MeOIstPyrd is an anti-skin cancer agent. MeOIstPyrd inhibits cell proliferation, migration, and spheroid formation by activating the mitochondrial intrinsic apoptotic pathway. MeOIstPyrd induces DNA damage. MeOIstPyrd activates p53, and increases the half-life of p53 and stabilizes p53 by phosphorylating it at ser15. MeOIstPyrd binds to MDM2 in the p53 sub-pocket and blocks p53-MDM2 interaction[1].
CAS Number
2308548-54-9
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/meoistpyrd.html
Purity
99.84
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=CC=C(NC(/C2=N\NC(N3CCCC3)=S)=O)C2=C1
Molecular Formula
C14H16N4O2S
Molecular Weight
304.37
References & Citations
[1]Nerina Shahi, et al. 5-Methoxyisatin N (4) -Pyrrolidinyl Thiosemicarbazone (MeOIstPyrd) Restores Mutant p53 and Inhibits the Growth of Skin Cancer Cells, In Vitro. https://pubs.acs.org/doi/10.1021/acsomega.3c03824. ACS Omega 2023, 8, 35, 31998?2016.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

MeOIstPyrd
CAS Number2308548-54-9
PubChem CID168510604
IUPAC NameN-[(2-hydroxy-5-methoxy-1H-indol-3-yl)imino]pyrrolidine-1-carbothioamide
Molecular FormulaC14H16N4O2S
Molecular Weight304.37
XLogP3.1
Topological Polar Surface Area105
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity414
SMILES
COC1=CC2=C(C=C1)NC(=C2N=NC(=S)N3CCCC3)O
InChI
InChI=1S/C14H16N4O2S/c1-20-9-4-5-11-10(8-9)12(13(19)15-11)16-17-14(21)18-6-2-3-7-18/h4-5,8,15,19H,2-3,6-7H2,1H3
InChIKey
NTBIQBNFRATJGD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of MeOIstPyrd
CAS: 2308548-54-9
CID: 168510604
Formula: C14H16N4O2S
MW: 304.37
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight304.37
XLogP33.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass304.09939694
Monoisotopic Mass304.09939694
Topological Polar Surface Area105 Ų
Heavy Atom Count21
Formal Charge0
Complexity414
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA3475-5MeOIstPyrd

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