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Ellipticine

CAT: 0804-HY-15753-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15753-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
CAS Number
519-23-3
Product Name Alternative
NSC 71795
UNSPSC
12352005
Hazard Statement
H301
Target
Topoisomerase
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Ellipticine.html
Purity
99.59
Solubility
DMSO : 5.8 mg/mL (ultrasonic; warming)
Smiles
CC1=C(C=NC=C2)C2=C(C)C(N3)=C1C4=C3C=CC=C4
Molecular Formula
C17H14N2
Molecular Weight
246.31
Precautions
H301
References & Citations
[1]Stiborova M, et al. Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150 (1) :13-23.|[2]Stiborova M, et al. Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip Toxicol. 2011 Jun;4 (2) :98-105.|[3]Stiborova M, et al. The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN?) mice and pure enzymes. Int J Mol Sci. 2014 Dec 25;16 (1) :284-306.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Topo II
Citation 01
Front Cell Dev Biol. 2019 Sep 20;7:204.|J Adv Res. 2024 Apr:58:117-128.|J Cell Biol. 2023 Jan 2;222 (1) :e202202110.

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