5-hydroxytryptamine receptor 2A
5-HYDROXYTRYPTAMINE RECEPTOR
| Normalized name | 5-HYDROXYTRYPTAMINE RECEPTOR |
| Entry Type | UniProtKB unreviewed (TrEMBL) |
| Primary Accession | D2Y0Z2 |
| Uni Protkb Id | D2Y0Z2_HORSE |
| First Public Date | 2010-03-02 |
| Last Annotation Update Date | 2025-10-08 |
| Last Sequence Update Date | 2010-03-02 |
| Entry Version | 56 |
| Sequence Version | 1 |
| Annotation Score | 2 |
| Scientific Name | Equus caballus |
| Common Name | Horse |
| Taxon Id | 9796 |
| Lineage | EukaryotaMetazoaChordata+ 9 more... |
| Protein Existence | 2: Evidence at transcript level |
| Value | 5-hydroxytryptamine receptor 4 |
| Alternative Names | ECO:0000256, ARBA, ARBA00031928, Serotonin receptor 4... |
| Genes | ECO:0000313, EMBL, ADB43606.1, HTR4 |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity |
| Subunit | Interacts (via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin) |
| Subcellular Location | Cell membraneEndosome membrane |
| Similarity | Belongs to the G-protein coupled receptor 1 family |
| Transmembrane | Helical, 20, EXACT, 45, EXACTHelical, 57, EXACT, 79, EXACTHelical, 99, EXACT, 117, EXACT+ 4 more... |
| Domain | G-protein coupled receptors family 1 profile, 36, EXACT, 312, EXACT... |
| Keywords | ECO:0000256, ARBA, ARBA00022475, KW-1003, Cellular component, Cell membrane... ECO:0000256, ARBA, ARBA00023157, KW-1015, PTM, Disulfide bond... ECO:0000256, ARBA, ARBA00022753, KW-0967, Cellular component, Endosome... + 7 more... |
| References | 1, CI-9KAQPC85QK1ER, submission, Prause A.S., Guionaud C.T., Mevissen M., 5-hydroxytryptamine receptor 4 in equine brain., DEC-2009, EMBL/GenBank/DDBJ databases, NUCLEOTIDE SEQUENCE, ECO:0000313, EMBL, ADB43606.1... |
| Uni Prot K B Cross References | EMBL, GU289397, ProteinId, ADB43606.1, Status, -, MoleculeType, mRNA... AlphaFoldDB, D2Y0Z2, Description, -GO, GO:0010008, GoTerm, C:endosome membrane, GoEvidenceType, IEA:UniProtKB-SubCell... + 21 more... |
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