Anle138b

• Background:

  Anle138b is an oligomeric aggregation inhibitor that inhibits the formation of pathological prion protein (PrPSc) and α-synuclein aggregates in vitro. Anle138b prevents accumulation of PrPSc in the brain and the spleen. Anle138b exhibits neuroprotective effects in a Parkinson's disease mouse model and improves motor performance in an α-synucleinopathy model.

• Description:

  Synuclein aggregation inhibitor

• Product Name Alternative:

  3- (1,3-Benzodioxol-5-yl) -5- (3-bromophenyl) -1H-pyrazole, 5- (1,3-Benzodioxol-5-yl) -3- (3-bromophenyl) -1H-pyrazole, Anle 138b, CID 44608289

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein

• Purity:

  >98% (HPLC) ; NMR (Conforms)

• Weight:

  0.005

• Format:

  White powder

• Solubility:

  May be dissolved in DMSO (15 mg/ml, warm)

• Molecular Formula:

  C16H11BrN2O2

• Molecular Weight:

  343.2

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Wagner J. et al. (2013) Acta Neuropathol. 125 (6): 795-813.

• CAS Number:

  882697-00-9