Z-Guggulsterone

• Background :

  Z-Guggulsterine acts as a selective antagonist at farnesoid X receptors, and inhibits FXR transactivation. It is also a retinoic acid receptor (RAR) pathway inhibitor. Attenuates astrocyte-mediated neuroinflammation by inhibiting toll-like receptor 4 pathway.

• Description :

  FXR Antagonist

• Product Name Alternative :

  (Z) -Pregna-4,17 (20) -diene-3,16-dione

• UNSPSC :

  41116105

• Type :

  Antagonist

• Source :

  Synthetic

• Field of Research :

  Cancer | Apoptosis | Cell Signaling | Epigenetics and Nuclear Signaling | Nuclear Signaling Pathways | NFkB Pathway | Neuroscience | Neuroinflammation

• Purity :

  >98% (TLC) ; NMR (Conforms)

• Weight :

  0.005

• Format :

  Off-white powder

• Solubility :

  May be dissolved in DMSO (6 mg/ml, warm); or Ethanol (3 mg/ml, warm)

• Molecular Formula :

  C21H28O2

• Molecular Weight :

  312.5

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• CAS Number :

  39025-23-5