VPS35 Kit

VPS35 Kit

• Background: Vacuolar Protein Sorter-35 (VPS35) is a component of the retromer complex, which is essential for endosome-to-Golgi retrieval of membrane proteins. VPS35 mutations such as D620N have been linked to Parkinson’s Disease (PD) (1,2) and affect retromer function, protein homeostasis, and mitochondria (3).
• Description: Colorimetric measurement of VPS35
• Product Name Alternative: Vacuolar protein sorting-associated protein 35, MEM3, PARK17, VPS35 retromer complex component, maternal-embryonic 3, vesicle protein sortin 35, TCCCTA00141, FLJ10752
• UNSPSC: 12352203
• Species Reactivity: Human, Mouse, Rat
• Target: VPS35
• Applications: ELISA kit used to quantitate VPS35 in samples.
• Detection Method: Colorimetric Assay
• Assay Type: Sandwich
• Sample Type: Tissue | Cell Lysate
• Detection Range: 78.125 - 5000 pg/mL
• Sensitivity: 50 pg/mL
• Weight: 500
• Components: Anti-VPS35 Immunoassay Plate | 5X VPS35 Extraction Reagent | Recombinant VPS35 Standard | Standard and Sample Diluent (Red) | 10X Wash Buffer Concentrate | Anti-VPS35 Biotinylated Antibody Concentrate | Anti-VPS35 Biotinylated Antibody Diluent (Green) | 100X Streptavidin:HRP Concentrate | Streptavidin: HRP Diluent (Purple) | TMB Substrate | Stop Solution
• Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• References & Citations: 1. Vilarino-Guell, C. et al. (2011) Am J Hum Genet 89:162–167 2. Zimprich, A. et al. (2011) Am J Hum Genet 89:168–175 3. Rahman, A.A., Morrison, B.E. (2019) Neurosci 401:1-10.