RAB1A, Clone 4G10

CAT: 0400-SMC-613SSize: 12 µgDry Ice: NoHazardous: No
CAT#:0400-SMC-613SSize:12 µg
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Background
RAB1A is a small GTPase localized to the membranes of the endoplasmic reticulum (ER) and Golgi apparatus. It regulates vesicular trafficking between these compartments and is essential for maintaining cellular homeostasis. In the nervous system, RAB1A supports the transport of proteins critical for synaptic function and neuronal survival. It has been implicated in the regulation of growth hormone secretion and intracellular signaling pathways. Dysfunction of RAB1A-mediated trafficking contributes to ER stress and impaired proteostasis—key features of neurodegenerative diseases such as Parkinson’s and Alzheimer’s. As a regulator of early secretory pathways, RAB1A is a potential target for modulating protein misfolding and aggregation in neurodegeneration.
Description
Mouse Anti-Human RAB1A Monoclonal IgG1
CAS Number
9007-83-4
Specifications
Detects ~23 kDa. Cross-reacts with RAB1B and RAB1C.
Product Name Alternative
GTP binding protein RAB 1A, RAB 1, Rab 1A, Rab1A, RAB1A member RAS oncogene family, RAB1A_HUMAN, Ras related protein Rab 1A, Ras-related protein Rab-1A, YPT1-related protein, RAB1
Synonyms
RAB1A, Clone 4G10
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
5861
Swiss Prot
P62820
Accession Number
NP_004152.1
Cellular Locus
Cytoplasm | Endoplasmic reticulum | Endosome | Golgi apparatus | Membrane
Host
Mouse
Species Reactivity
Human, Mouse
Immunogen
Full length recombinant Human RAB1A protein
Target
RAB1A
Clonality
Monoclonal
Isotype
IgG1
Clone
4G10
Conjugation
Unconjugated
Tissue Specificity
Low tissue specificity.
Type
Monoclonal
Applications
WB | IP
Validated Applications
WB, IP
Field of Research
Cancer | Cell Signaling | Cell Signaling | Autophagy| Golgi Proteins | Alzheimer's Disease | Growth Factors | Membrane Trafficking Proteins | Neurodegeneration | Neuroscience | Parkinson's Disease | Protein Trafficking
Purification
Protein G Purified
Limit Of Detection
A 1:1000 dilution of SMC-613 was sufficient for detection of RAB1A in 10 ug (A549, MEF) ; 20 ug (Mouse Brain) lysates by ECL immunoblot analysis.
Concentration
1mg/ml
Dilution
WB (1:1000) ; optimal dilutions for assays should be determined by the user.
Weight
0.012
Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Yang, X. et al. (2016) Oncogene. 35(44):5699-5704 2. pubchem.ncbi.nlm.nih.gov/protein/P62820
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects ~23 kDa. Cross-reacts with RAB1B and RAB1C.
Background Reference 01
1. Yang, X. et al. (2016) Oncogene. 35 (44) :5699-5704 2. pubchem.ncbi.nlm.nih.gov/protein/P62820
Species
Human | Mouse
Location
Cytoplasm | Endoplasmic reticulum | Endosome | Golgi apparatus | Membrane
Isotype
IgG1
Immunogen Species
Human

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