RAB1A, Clone 4G10

• Background:

  RAB1A is a small GTPase localized to the membranes of the endoplasmic reticulum (ER) and Golgi apparatus. It regulates vesicular trafficking between these compartments and is essential for maintaining cellular homeostasis. In the nervous system, RAB1A supports the transport of proteins critical for synaptic function and neuronal survival. It has been implicated in the regulation of growth hormone secretion and intracellular signaling pathways. Dysfunction of RAB1A-mediated trafficking contributes to ER stress and impaired proteostasis—key features of neurodegenerative diseases such as Parkinson’s and Alzheimer’s. As a regulator of early secretory pathways, RAB1A is a potential target for modulating protein misfolding and aggregation in neurodegeneration.

• Description:

  Mouse Anti-Human RAB1A Monoclonal IgG1

• Specifications:

  Detects ~23 kDa. Cross-reacts with RAB1B and RAB1C.

• Product Name Alternative:

  GTP binding protein RAB 1A, RAB 1, Rab 1A, Rab1A, RAB1A member RAS oncogene family, RAB1A_HUMAN, Ras related protein Rab 1A, Ras-related protein Rab-1A, YPT1-related protein, RAB1

• Synonyms:

  RAB1A, Clone 4G10

• UNSPSC:

  12352203

• UN Code:

  Non-hazardous

• Hazard Statement:

  Non-hazardous

• Gene ID:

  5861

• Swiss Prot:

  P62820

• Accession Number:

  NP_004152.1

• Cellular Locus:

  Cytoplasm | Endoplasmic reticulum | Endosome | Golgi apparatus | Membrane

• Host:

  Mouse

• Species Reactivity:

  Human, Mouse

• Immunogen:

  Full length recombinant Human RAB1A protein

• Target:

  RAB1A

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Clone:

  4G10

• Conjugation:

  Unconjugated

• Tissue Specificity:

  Low tissue specificity.

• Type:

  Monoclonal

• Applications:

  WB | IP

• Validated Applications:

  WB, IP

• Field of Research:

  Cancer | Cell Signaling | Cell Signaling | Autophagy| Golgi Proteins | Alzheimer's Disease | Growth Factors | Membrane Trafficking Proteins | Neurodegeneration | Neuroscience | Parkinson's Disease | Protein Trafficking

• Purification:

  Protein G Purified

• Limit Of Detection:

  A 1:1000 dilution of SMC-613 was sufficient for detection of RAB1A in 10 ug (A549, MEF) ; 20 ug (Mouse Brain) lysates by ECL immunoblot analysis.

• Concentration:

  1mg/ml

• Dilution:

  WB (1:1000) ; optimal dilutions for assays should be determined by the user.

• Weight:

  0.012

• Buffer:

  PBS pH7.4, 50% glycerol, 0.09% sodium azide

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Yang, X. et al. (2016) Oncogene. 35(44):5699-5704 2. pubchem.ncbi.nlm.nih.gov/protein/P62820

• Shipping Conditions:

  Blue Ice or 4ºC

• Storage Conditions:

  -20ºC

• Specificity:

  Detects ~23 kDa. Cross-reacts with RAB1B and RAB1C.

• Background Reference 01:

  1. Yang, X. et al. (2016) Oncogene. 35 (44) :5699-5704 2. pubchem.ncbi.nlm.nih.gov/protein/P62820

• Species:

  Human | Mouse

• CAS Number:

  9007-83-4

• Location:

  Cytoplasm | Endoplasmic reticulum | Endosome | Golgi apparatus | Membrane

• Isotype:

  IgG1

• Immunogen Species:

  Human