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WZ811

CAT: 0804-HY-15478-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15478-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WZ811 is an orally active, highly potent competitive antagonist of CXCR4. WZ811 efficiently inhibits CXCR4/SDF-1 (or CXCL12) -mediated modulation of cAMP levels (EC50=1.2 nM) and SDF-1 induced Matrigel invasion in cells (EC50=5.2 nM) [1].
CAS Number
55778-02-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/wz811.html
Purity
99.80
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
C1(CNC2=NC=CC=C2)=CC=C(CNC3=NC=CC=C3)C=C1
Molecular Formula
C18H18N4
Molecular Weight
290.36
Precautions
H302, H315, H319, H335
References & Citations
[1]WZ811, et al. Discovery of small molecule CXCR4 antagonists. J Med Chem. 2007 Nov 15;50 (23) :5655-64.|[2]Li SH, et al. Suppression of chronic lymphocytic leukemia progression by CXCR4 inhibitor WZ811. Am J Transl Res. 2016 Sep 15;8 (9) :3812-3821.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR4

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