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Liquiritigenin

CAT: 0804-HY-N0377-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0377-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC50 of 36.5 nM for activation of the ERE tk-Luc.
CAS Number
578-86-9
Product Name Alternative
4',7-Dihydroxyflavanone
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Estrogen Receptor/ERR
Type
Natural Products
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Liquiritigenin.html
Concentration
10mM
Purity
99.76
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(O)=CC=C13
Molecular Formula
C15H12O4
Molecular Weight
256.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Mersereau JE, et al. Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol Cell Endocrinol. 2008 Feb 13;283 (1-2) :49-57.|[2]Suh KS, et al. Protective effect of liquiritigenin against methylglyoxal cytotoxicity in osteoblastic MC3T3-E1 cells. Food Funct. 2014 Jul 25;5 (7) :1432-40.|[3]Tao W, et al. Liquiritigenin reverses depression-like behavior in unpredictable chronic mild stress-induced mice by regulating PI3K/Akt/mTOR mediated BDNF/TrkB pathway. Behav Brain Res. 2016 Jul 15;308:177-86.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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