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Sinbaglustat

CAT: 0804-HY-129411-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-129411-01Size:5 mg
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Description
Sinbaglustat (OGT2378) is a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2) . Sinbaglustat is an orally available N-alkyl iminosugar that crosses the blood-brain barrier. Sinbaglustat can be used for the research of central neurodegenerative diseases associated with lysosomal dysfunctions[1][2].
CAS Number
441061-33-2
Product Name Alternative
ACT-519276; OGT2378
UNSPSC
12352005
Target
Glucosylceramide Synthase (GCS)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sinbaglustat.html
Purity
99.83
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@H](CO)N(CCCCC)C[C@H](O)[C@H]1O
Molecular Formula
C11H23NO4
Molecular Weight
233.30
References & Citations
[1]Michael Weiss, et al. Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase. Cancer Res. 2003 Jul 1;63 (13) :3654-8. |[2]Martine Gehin, et al. Assessment of Target Engagement in a First-in-Human Trial with Sinbaglustat, an Iminosugar to Treat Lysosomal Storage Disorders. Clin Transl Sci. 2021 Mar;14 (2) :558-567.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
BA8493-5.1Sinbaglustat

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