NQO1 substrate

• Description:

  NQO1 substrate acts as an efficient NQO1 substrate and may be a new option for the treatment of NQO1-overexpresssing drug-resistant NSCLC[1].

• Product Name Alternative:

  AM152

• UNSPSC:

  12352005

• Target:

  Quinone Reductase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nqo1-substrate.html

• Purity:

  98.02

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  N#CC1=C (C#N) N=C2C (C (C3=C2C=C (F) C (F) =C3) =O) =N1

• Molecular Formula:

  C13H2F2N4O

• Molecular Weight:

  268.18

• References & Citations:

  [1]Wu X, et al. Discovery of Nonquinone Substrates for NAD (P) H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer. J Med Chem. 2018 Dec 27;61 (24) :11280-11297.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2304503-05-5